什么时候停止抗生素在重症患者?
Nathan D Nielsen1,2, James T Dean1, Elizabeth A Shald3
1Division of Pulmonary, Critical Care and Sleep Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
对于重症患者来说,抗生素管理至关重要,以尽量减少抗菌素耐药性 (AMR) 等风险. 使用生物标志物和跨学科团队的多模式方法可以指导适当的抗生素持续时间.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在过去的一个世纪里,抗生素的使用在重症患者中显著增加.
- 人们越来越担心适当的抗生素治疗指南和持续时间.
- 抗生素的使用带有短期 (肝/功能障碍),中期 (超级感染) 和长期 (抗菌素耐药性) 的风险,长期或广泛使用会加剧这种风险.
研究的目的:
- 审查确定适当的抗微生物药物治疗持续时间的策略.
- 要突出临床转向多模式方法优化抗生素戒断的临床转变.
- 提出一种综合方法,以便在抗生素治疗中做出明智的临床决策.
主要方法:
- 文献综述侧重于抗菌药物治疗持续时间的策略.
- 对抗生素疗程多模式决策的临床趋势的分析.
- 构想一种整合生物标志物测试和跨学科团队的方法.
主要成果:
- 越来越多地关注确定最佳抗菌药物治疗持续时间的策略.
- 新兴的临床趋势是针对抗生素戒断的多模式策略.
- 确定生物标志物分析和跨学科合作作为未来决策的关键组成部分.
结论:
- 优化抗生素持续时间对于减轻治疗风险和打击抗菌素耐药性 (AMR) 是必不可少的.
- 多模式方法,将生物标记数据与跨学科团队 (药剂师,护士,医生,微生物学家) 的投入相结合,代表了在抗生素治疗中基于证据的临床决策的有希望的策略.
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