用塞福洛キシ姆治疗的肺炎炎患者住院治疗不适当治疗的影响:一组队列研究
Jorge Alberto Cortés1,2, Claudia Rocío Sierra3, Ricardo Sánchez4
1Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Sede Bogotá, Bogotá 111321, Colombia.
Antibiotics (Basel, Switzerland)
|March 27, 2024
概括
在社区获得的成年人肺炎中,不适当的抗生素治疗并没有增加住院或再入院的时间. 这项研究评估了对大肠杆菌感染的塞福洛キシ姆治疗有效性.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 社区获得性肺炎 (CAP) 是一种常见的细菌感染.
- 大肠杆菌是最常见的CAP病原体.
- 经验性抗生素治疗是标准的,但耐药性会导致不适当的治疗.
研究的目的:
- 评估不适当的经验性 cefuroxime 治疗对 E. coli CAP. 的成年患者的影响.
- 为了确定不适当的治疗是否会影响住院时间和30天再入院率.
主要方法:
- 从2013年到2020年,对747名成年患有大肠杆菌CAP的成年患者进行了回顾性队列研究.
- 不适当的治疗被定义为基于尿液培养的不敏感分离物的治疗.
- 倾向性得分权重用于调整混因素.
主要成果:
- 102名患者 (13.7%) 接受了不适当的治疗.
- 在调整后,不适当的治疗与停留时间的缩短有关 (HR=0.34;95% CI=0.23-0.49).
- 不适当的治疗与30天的再入院没有显著的关系 (OR=1.47;95% CI=0.35-2.79).
结论:
- 在成年人中对大肠杆菌CAP进行不适当的经验性 cefuroxime 治疗与更长的住院时间无关.
- 不适当的治疗并没有增加这个患者队列30天再入院的风险.
- 调查结果表明,必须仔细考虑对抗生素的管理,以确保农业农业政策的管理.
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