基于微生物的生物活性化合物可缓解肥胖症的炎症
Oladayo Emmanuel Apalowo1, Grace Adeola Adegoye2, Tolulope Mobolaji Obuotor3
1Department of Food Science, Nutrition and Health Promotion, Mississippi State University, Starkville, MS 39762, USA.
Current issues in molecular biology
|March 27, 2024
概括
肠道微生物群的失调有助于肥胖和炎症. 生物活性化合物如益生菌和益生菌可以降低肠道透性和炎症,有助于肥胖管理.
科学领域:
- 代谢障碍和衰老的发生
- 肠道微生物组和炎症的发生
背景情况:
- 肥胖和相关的代谢障碍是全球流行病.
- 肠道微生物群在新陈代谢和炎症中起着关键作用,但其复杂性阻碍了研究.
- 不调节的肠道微生物群有助于炎症,这是与衰老和慢性疾病相关的慢性炎症状态.
研究的目的:
- 探索益生菌,益生菌,共生菌和后生菌的功能作用.
- 要突出它们在减少肠道超透性,增强肠道屏障功能和抑制促炎途径方面的贡献.
主要方法:
- 审查生物活性化合物的功能作用 (前生物,益生菌,共生菌,后生物).
- 专注于包括脂聚糖 (LPS) 失活,紧结蛋白上调和抗炎途径抑制在内的机制.
主要成果:
- 生物活性化合物可以通过非活性化LPS来降低肠道的超透性.
- 这些化合物可以通过调节紧密结合蛋白来增强肠道屏障功能.
- 它们通过抑制促炎途径,有助于缓解慢性炎症.
结论:
- 益生菌,益生菌,共生菌和后生菌在控制肥胖方面显示出潜在的潜力.
- 这些干预措施可以通过改善肠道健康和减少炎症来减轻炎症.
- 准肠道微生物群为代谢障碍管理提供了一个有希望的策略.
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