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Updated: Jun 29, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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通过Brd4-关联蛋白和细胞周期控制蛋白p21探索β细胞SASP的转录调节

Jasmine Manji1,2, Jasmine Pipella1,2, Gabriel Brawerman1,2

  • 1Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.

Epigenomes
|March 27, 2024
PubMed
概括

1型糖尿病涉及β细胞衰老和SASP. 原体外终端 (BET) 蛋白 Brd4 与衰老β细胞中的染色质重塑剂相互作用,这表明它在调节这一过程中发挥了作用.

关键词:
在 SASP 找 SASP原蛋白外终端域蛋白质细胞衰老 细胞衰老胰腺β细胞是胰腺β细胞.第1类糖尿病 1型糖尿病

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