SARS-CoV-2 感染是肝硬化患者脱补偿的独立风险因素
Mark Ayoub1, Julton Tomanguillo1, Carol Faris2
1Department of Internal Medicine, Charleston Area Medical Center, West Virginia University, Charleston, WV 25304, USA.
在补偿性肝硬化患者中,SARS-CoV-2显著增加了失补偿,死亡率和并发症. 这种病毒在三个月内使这些不良事件的风险增加了一倍以上.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- SARS-CoV-2 感染呈现出各种胃肠道症状.
- 肝硬化患者,特别是那些患有失补偿性疾病的患者,有较高的SARS-CoV-2死亡率.
- 这项研究调查了SARS-CoV-2对补偿性肝硬化患者脱补偿的影响.
研究的目的:
- 为了评估SARS-CoV-2感染对先前补偿的肝硬化患者脱补偿的影响.
- 评估SARS-CoV-2对该患者群体的死亡率和胃肠道出血的影响.
主要方法:
- 对16个国家的全球协作网络数据库 (TriNetX) 的分析.
- 创建了两组可比的补偿性肝硬化患者队列,使用1:1的倾向性得分匹配:SARS-CoV-2阳性与阴性.
- 在感染后1个月和3个月评估脱补偿,死亡率和胃肠道出血.
主要成果:
- 阳性SARS-CoV-2患者表现出显著更高的脱补偿率 (4.4%与1.9%在1个月;6%与2.6%整体).
- 观察到并发症的发生率增加,包括,自发细菌性腹膜炎 (SBP),肝脑病变 (HE) 和肝综合征 (HRS).
- 在SARS-CoV-2阳性患者中,1个月和3个月的死亡率和胃肠道出血率也较高.
结论:
- 在补偿性肝硬化患者中,SARS-CoV-2 感染将减补偿的风险增加一倍以上.
- 该病毒与1至3个月内死亡率和并发症率的增加有关.
- 这些发现凸显了补偿性肝硬化患者对SARS-CoV-2的高度脆弱性.
更多相关视频
07:30Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
04:00Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
相关概念视频
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Acute Respiratory Failure-III
Esophageal Varices-I: Introduction
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
