在患有结肠直肠癌的患者中,对治疗前的炎症概况进行探索性评估
Catalin Vladut Ionut Feier1,2, Calin Muntean3, Sorana D Bolboacă4
1First Discipline of Surgery, Department X-Surgery, "Victor Babeș" University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
Diseases (Basel, Switzerland)
|March 27, 2024
概括
诸如系统性炎症总指数 (AISI) 和系统性炎症反应指数 (SII) 这样的炎症标志物可以预测结直肠癌患者的结果. 升高的水平表明死亡和并发症的风险更高,有助于预后.
科学领域:
- 在瘤学瘤学.
- 炎症生物学 炎症生物学
- 外科手术的结果
背景情况:
- 结肠直肠癌 (CRC) 是一个重大的全球健康挑战,发病率和死亡率很高.
- 在CRC中,预后指标对于有效的患者管理和治疗策略至关重要.
- 系统性炎症在CRC预后中的作用需要进一步阐明.
研究的目的:
- 研究手术治疗结直肠癌患者手术前炎症标志物的预后价值.
- 评估炎症比率与患者结果之间的关联,包括死亡率,ICU入院和并发症.
主要方法:
- 对接受手术的结直肠癌患者7年的数据进行了回顾性分析.
- 从完整的周围血液细胞计数中得出的六种炎症比率的评估.
- 患者群体之间的标志物水平的统计比较,结果不同 (出院与死亡,ICU与没有ICU,并发症与没有并发症).
主要成果:
- 较高的手术前系统炎症综合指数 (AISI) 和系统炎症反应指数 (SII) 与术后死亡率有关.
- 中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞的比率,AISI和SII在需要重症监护室 (ICU) 监测的患者中有显著差异.
- 在患有并发症的患者中观察到较高的AISI水平,例如肠道.
结论:
- 手术前的炎症生物标志物是结直肠癌的宝贵预后工具.
- 这些标记可以帮助预测患者的预后,识别高风险个体.
- 进一步的研究可以将这些标记物纳入用于CRC管理的临床决策中.
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