最近关于DNA甲基化和基因组修饰在全身性硬化症中的作用的见解:一个范围审查
Tsvetelina Kostova1,2, Rositsa Karalilova1,2, Zguro Batalov1,2
1Department of Propedeutics of Internal Diseases, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Diagnostics (Basel, Switzerland)
|March 27, 2024
概括
系统性硬化症涉及复杂的表观遗传变化,包括DNA甲基化和基因素修饰. 了解这些表观遗传变化为针对这种特异性疾病的新疗法提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 系统性硬化症是一种复杂的异常性自身免疫性疾病.
- 它的发病包括遗传易感性,环境因素和表观遗传修饰.
- 表观遗传失调越来越被认为是关键因素.
研究的目的:
- 在过去十年中,绘制基因甲基化和系统性硬化症中基因素修饰的进展.
- 审查表观遗传扰乱对疾病发病的贡献.
- 在表观遗传机制中识别潜在的治疗点.
主要方法:
- 使用了一个范围审查方法.
- 在Scopus,Web of Science和PubMed数据库中进行文献搜索.
- 选择和分析了44项相关研究.
主要成果:
- 表观遗传干扰,特别是DNA甲基化和基因素修饰,在全身性硬化症的发病过程中发挥着关键作用.
- 这些变化影响了参与疾病的多种细胞类型.
- 在过去的十年里,已经有了重要的发现.
结论:
- 该审查强调了在理解系统性硬化症中的表观遗传作用方面取得的重大进展.
- 对DNA甲基化和基因组修饰的进一步研究至关重要.
- 针对表观遗传标记为系统性硬化症提供了新的治疗可能性.
相关概念视频
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02:25Overview of DNA Repair
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...