根据免疫组织化学分子分类的侵袭性叶状乳腺癌的组织学亚型的差异
Ivan Ilić1, Jana Cvetković2, Ratko Ilić1
1Center for Pathology and Pathological Anatomy, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Diagnostics (Basel, Switzerland)
|March 27, 2024
概括
这项研究比较了侵袭性叶膜癌 (ILC) 的组织学和分子亚型. 经典的ILC与Luminal A分子亚型显示出基于免疫组织化学标记的最有利的预后.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 分子生物学分子生物学
背景情况:
- 基因表达分析的复杂性需要使用免疫组织化学来对乳腺癌进行替代分子分类.
- 侵袭性叶状癌 (ILC) 由于其多样化的组织学亚型和分子异质性,提出了诊断挑战.
- 准确的分类对于预测ILC行为,预后和指导治疗决策至关重要.
研究的目的:
- 为了比较侵袭性叶膜癌 (ILC) 的组织学和分子亚型.
- 为了确定ILC亚型和分子分类之间的相关性.
- 提高预测ILC行为,预后,并优化治疗策略.
主要方法:
- 分析了263例在7年内诊断的侵袭性叶状癌 (ILC) 病例.
- 基于特征性生长模式和细胞表型 (古典,膜,固体,管状,形,混合) 的组织学亚型.
- 使用免疫组织化学标记物分为五组的分子分类:ER,PR,HER2,Ki67.
主要成果:
- 形ILC亚型在Luminal A分子亚型 (p=0.00027) 中的频率明显低.
- 在ILC的pT4阶段,HER2丰富的分子亚型明显更常见 (p=0.024).
- 在ILC的组织学和分子特征之间确定了特定的关联.
结论:
- 光线性A分子亚型,特别是在经典的ILC中,显示出预测/预后免疫组织化学标志物中最有利的特征.
- 了解ILC组织学和分子亚型之间的相互作用对于个性化医学至关重要.
- 这项研究为完善ILC分类和治疗方法提供了基础.
相关概念视频
Classification of Epithelial Tissues: Overview
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Based on the number of cell layers,...
Classification of Epithelial Tissues: Stratified Epithelium
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
Classification of Epithelial Tissues: Glandular Epithelium
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
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