在中年成年人中探索系统性炎症标志物和动脉动脉样硬化指数之间的相关性:一项横截面研究
Ji-Eun Song1, Ji-In Hwang1, Hae-Jin Ko2,3
1Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.
Journal of cardiovascular development and disease
|March 27, 2024
概括
系统性炎症标志物,如中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR),与中年成年人动脉样硬化相关. 这些标记物显示出潜在的预测因素,用于评估动脉斑块负担.
科学领域:
- 心血管研究研究心血管研究
- 炎症生物学 炎症生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 动脉样硬化是一种重要的心血管疾病.
- 系统性炎症在动脉样硬化发展中起作用.
- 确定可靠的动脉样硬化炎症标志物至关重要.
研究的目的:
- 为了研究系统性炎症标志物与动脉样硬化之间的关联.
- 评估C反应蛋白 (CRP) 的潜力,红细胞沉积率 (ESR),中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 作为预测因素.
主要方法:
- 对1264名韩国成年人 (40-65岁) 的回顾性横截面研究.
- 评估了炎症标志物 (CRP,ESR,NLR,PLR) 和大脑动脉指标 (cIMT,PN,PSS,PS).
- 使用线性回归,逻辑回归和ROC分析.
主要成果:
- 在男性中,ESR和CRP与斑块数 (PN) 相相关;在女性中,ESR与PN相相关.
- 在两种性别中,NLR和PLR与斑块得分 (PS) 相相关.
- NLR显示了增加动脉内膜介质厚度 (cIMT) 和斑块评分 (PS) 的预测价值.
结论:
- NLR和PLR与动脉动脉样硬化有显著的相关性.
- 作为动脉动脉样硬化症的替代标记物,NLR和PLR显示出有前途.
- 建议进行进一步的前性研究,以确认它们的预测效果.
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