静脉间隔隔膜干扰与膜功能和力学在膜高性心肌病症中更严重的损伤有关
Christos G Mihos1,2, Tarec K Elajami2, Deepika Misra2
1Echocardiography Laboratory, Columbia University Irving Medical Center, Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL 33140, USA.
Journal of cardiovascular development and disease
|March 27, 2024
概括
与隔离的缩性心肌病 (ApHCM-Pure) 相比,在缩性心肌病 (ApHCM-Mixed) 中 Septal 的参与导致了更糟糕的心室功能和机制. 这种独特的ApHCM混合形态与双心室功能受损和心脏事件增加有关.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 心脏机械学 心脏机械学
背景情况:
- 腹腔间隔膜在双腹腔的表现中起着至关重要的作用.
- 脊柱上垂体缩性心肌病 (ApHCM) 呈现各种形式,包括孤立的脊柱上垂体缩 (ApHCM-纯) 和混合的隔膜干涉 (ApHCM-混合).
研究的目的:
- 为了研究隔膜干扰在心室结构和功能的ApHCM-Mixed对心室结构和功能的影响,而不是APHCM-Pure.
- 描述这两个ApHCM亚型之间的心室力学和临床结果的差异.
主要方法:
- 在72名患者 (36 ApHCM-混合,36 ApHCM-纯) 进行了连续的2D和斑点跟踪回声心脏学.
- 用左 (LV) 和右 (RV) 心室的全球纵向应变 (GLS),RV自由壁应变和LV心肌工作指数来评估心室功能和机制.
- 临床事件被判定为平均随访时间为3.9年.
主要成果:
- 与ApHCM混合组相比,ApHCM混合组的LV质量指数较大,LV和RV GLS明显较差,RV自由壁应变受损,LV心肌工作指数减少.
- 这些功能和机械差异在随访期间持续存在.
- 仅在ApHCM混合组中发生了5例死亡 (14%),其中4例与心脏有关,表明显著的亚临床双心室功能障碍.
结论:
- ApHCM-Mixed代表了高缩性心肌病的独特形态亚型.
- 这种亚型与APHCM-Pure相比,与更受损的心室功能和力学有关.
- 在ApHCM中 Septal 的参与会对双心室性能产生不利影响,并且可能与较差的临床结果有关.
关键词:
亚皮性过度缩性心肌病变 (APICAL HYPERTROPHIC CARDIOMYOPATHY) 这是一种心肌病变.心脏机械学心脏机械学全球纵向菌株全球纵向菌株心肌功能的工作.斑点跟踪回声心脏图谱 (speckle-tracking echocardiography) 是一种跟踪斑点的回声心脏图谱.应变回声心电图是压力回声心电图.更多相关视频
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