来自Xylaria spp 的二次代谢物的结构和生物活动
Weikang Chen1,2, Miao Yu1,2, Shiji Chen1,2
1Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Journal of fungi (Basel, Switzerland)
|March 27, 2024
概括
菌类Xylaria产生许多具有显著生物活动的新型化合物. 本综述详细介绍了445种二次代谢物及其在农业和医学中开发新天然药物的潜力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 菌类Xylaria属是结构多样化和生物活性二次代谢物的丰富来源.
- 这些化合物在制药和农业应用中具有重大药物发现潜力.
研究的目的:
- 审查来自Xylaria spp.的二次代谢物的结构. 发表于1994年至2024年1月之间.
- 为了记录与这些Xylaria衍生化合物相关的生物活动.
- 为未来的研究提供指南,研究来自Xylaria的新型天然产品.
主要方法:
- 对Xylaria二次代谢物及其活动进行全面的文献搜索.
- 报告的化合物的结构阐明和分类.
- 编制和分析生物活动数据.
主要成果:
- 总共有445种来自Xylaria spp.的新化合物. 确定了包括特类,含的化合物,多基类和乳类的物质.
- 其中177种化合物表现出显著的生物活性,如细胞毒性,抗微生物,抗炎症,抗真菌,免疫抑制和酶抑制作用.
- 该审查涵盖1994年至2024年1月期间.
结论:
- 紫菌是新型生物活性天然产品的丰富资源.
- 记录的化合物和活动突出了Xylaria代谢物的潜力,用于开发新的治疗药物.
- 对西拉利亚天然产品的进一步研究可以对农业和医药的进步做出重大贡献.
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