肠道微生物组和喘
Amjad N Kanj1, Joseph H Skalski1
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
Journal of fungi (Basel, Switzerland)
|March 27, 2024
概括
肠道真菌 (肠道菌群) 的变化与喘的发展和严重程度有关. 肠道真菌不平衡会影响肺部免疫力,可能增加喘风险,并使成人和儿童的症状恶化.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 肠-肺轴描述了肠和肺之间的双向通信.
- 肠道微生物组中的共体真菌在免疫系统调节中发挥作用.
- 喘是一种由免疫反应影响的慢性呼吸道疾病.
研究的目的:
- 审查肠道真菌生物在喘中的作用.
- 探索肠道真菌失生症如何影响肺部免疫力和喘.
- 讨论潜在的治疗策略,针对喘的肠道菌群.
主要方法:
- 关于喘中的肠道菌群组成研究的综合文献综述.
- 对动物模型进行分析,详细说明肠肺相互作用机制.
- 综合了有关参与肠肺通信的免疫通路的数据.
主要成果:
- 肠道真菌失生症,特别是Candida的增加,与儿童喘风险升高和成人喘恶化有关.
- 这些机制包括宿主免疫感应 (C型乳受体),真菌代谢物 (12,13-diHOME) 和肺免疫细胞 (ILC2s,M2巨细胞).
- 肠道真菌生物组调节被提议作为严重喘的治疗途径.
结论:
- 肠道真菌失生症是喘发病的一个重要因素.
- 进一步的研究至关重要,以充分阐明肠道菌群在喘中的作用.
- 准肠道菌群可能为喘提供新的治疗策略.
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