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蛋白质摄入量与糖尿病并发症风险之间的关联 发生后的2型糖尿病:EPIC-波茨坦研究
Elif Inan-Eroglu1,2, Olga Kuxhaus1,2, Franziska Jannasch1,2
1Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.
Metabolites
|March 27, 2024
概括
在2型糖尿病 (T2D) 诊断后改变蛋白质摄入量并没有显著改变并发症风险. 用蛋白质取代碳水化合物显示出降低风险的趋势,但对于T2D患者而言没有统计学意义.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 关于蛋白质摄入量和2型糖尿病 (T2D) 并发症的现有研究主要集中在被诊断出来的个体上.
- 关于T2D诊断后蛋白质消费的修改如何影响并发症风险的数据有限.
研究的目的:
- 研究总体,动物和植物蛋白摄入量与发生T2D患者的血管并发症之间的关联.
- 要考虑诊断前的蛋白质摄入量和T2D诊断后的摄入量变化.
主要方法:
- 对来自EPIC-波茨坦队列的1,064名参与者进行前性队列研究,他们患有T2D.
- 在基线和随访时通过食物频率问卷评估的饮食蛋白质摄入量.
- 分析了医生报告的糖尿病并发症事件 (大血管和小血管).
主要成果:
- 用蛋白质取代碳水化合物显示出非显著的趋势,导致并发症风险降低 (HR:0.83;95% CI:0.60-1.14).
- 诊断后增加的蛋白质摄入量取代碳水化合物并没有与总或微血管并发症有关.
- 在T2D病例中用蛋白质代替碳水化合物时,没有观察到糖尿病并发症的风险增加.
结论:
- 修改蛋白质摄入量,特别是用蛋白质取代碳水化合物,似乎不会增加新诊断T2D的人的血管并发症风险.
- 可能需要进一步的研究来证实碳水化合物与蛋白质的替代减少风险的潜在趋势.
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