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基斯乙化增强宿主化作为对寄生虫的反应寄生虫由内寄生虫黄蜂

Kun Jiang^1,2, Yan Zhou^1,2, Wen Cui^1,2

¹State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

|March 27, 2024

概括

缺少多纳病毒的内寄生虫黄蜂使用基因素乙化来抑制宿主免疫力. 这种表观遗传修饰针对关键基因,导致宿主免疫抑制和寄生虫生存.

科学领域:

昆虫生物学昆虫生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
寄生虫与宿主之间的相互作用

背景情况:

内寄生虫 (Endoparasitoids) 是一种在其他昆虫体内产卵的昆虫.
一些寄生虫使用多纳病毒来抑制宿主免疫力,但缺乏病毒的物种的机制是未知的.
氨酸乙化 (LysAc) 是基因表达的关键表观遗传调节剂.

研究的目的:

为了调查缺乏多病毒的内寄生虫是否利用LysAc进行宿主免疫操纵.
探索 LysAc 在 Chalcidoidea 黄蜂 (Tetrastichus brontispae) 的生存策略中的作用.

主要方法:

蛋白质组学和LysAc修饰组学被用于分析宿主基因表达.
这项研究的重点是内寄生虫*Tetrastichus brontispae*及其宿主*Octodonta nipae*.
进行了对基因脱乙酶Rpd3的基因淘汰.

主要成果:

由 *T. brontispae* 寄生,减少了 Rpd3 的表达和增加了 LysAc 基因组 H3.3K9 和 H3.3K14 的修饰.
Knockdown 的 Rpd3 提高了参与氧化酶级联 (OnPPAF1 和 OnPPO) 的基因的表达.
这导致宿主黑化和死,模仿木乃伊化.

结论:

没有多核虫病毒的内寄生虫可以使用基因素乙化来调节与宿主免疫相关的基因.
LysAc 修饰是内寄生虫生存策略的关键机制.
这项研究提供了关于昆虫宿主操纵中的表观遗传调节的见解.

关键词:

八条龙 (Octodonta nipae) 是一个有八条龙的动物.泰特拉斯提克斯 (Tetrastichus brontispae) 是一个的鱼类.表观遗传学是指表观遗传学.基因素乙化基因素乙化基因素乙化黑色化是指黑色化的过程.寄生主义是一种寄生主义.

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