基于藻类的纳米粒子用于口服药物输送系统
Eliyahu Drori1, Dhaval Patel1, Sarah Coopersmith1
1Department of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel.
Marine drugs
|March 27, 2024
概括
可食用藻类可以转化为纳米粒子 (NP) 用于口服药物输送. 螺旋藻衍生的NP表现出强大的粘膜粘附性和增强细胞吸收,证明了它们作为有效药物递送载体的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服药物输送是首选的,但面临着诸如低吸收和毒性等挑战.
- 粘粘性载体可以提高药物的停留时间和胃肠道中的全身吸收.
- 藻类材料为开发新型药物输送系统提供了可持续和生物相容的来源.
研究的目的:
- 从食用藻类生产和表征仿生纳米颗粒 (aNP) 用于口服药物输送.
- 评估这些aNPs的粘膜粘合性和细胞吸收.
- 为藻类纳米颗粒作为口服药物输送载体建立概念验证.
主要方法:
- 14种可食用的藻类被用来制造藻类纳米粒子 (aNPs).
- aNP的特点是大小,表面电荷,形态,封装效率和粘膜粘合.
- 在小鼠,猪和绵羊的肠道模型上进行了ex vivo粘合测试.
- 使用Caco-2细胞评估了细胞吸收.
主要成果:
- aNPs显示球形形态,尺寸从126-606nm,表面电荷从-9到-38mV.
- 在不同藻类和动物模型中观察到粘膜粘合力的显著变化.
- 来自Arthospira platensis (Spirulina) 的NP显示出最高的粘粘度 (高达3127±272μN/mm2).
- 在高粘粘力和增强的细胞吸收到Caco-2细胞之间发现了正相关性.
结论:
- 藻类纳米粒子 (aNP) 显示出作为有效的口服药物递送系统的潜力.
- 螺旋藻衍生的纳米颗粒表现出优异的粘膜粘合特性,并促进细胞吸收.
- 这些发现支持使用aNPs来改善人类肠道上皮的药物吸收.
相关概念视频
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
828
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
828
01:18Drug Delivery: Enteral Route
437
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
437
01:16Drug Delivery: Overview
290
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
290
01:18Routes of Drug Administration: Enteral
3.6K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.6K