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神经活性脂的新形式用于大脑中的DHA丰富

Romina Gomes^1,2, Inês Mendes^1,3, Maria Paula Duarte²

¹Division of Aquaculture, Upgrading and Bioprospection (DivAV), Portuguese Institute for the Sea and Atmosphere (IPMA, I.P.), Avenida Alfredo Magalhães Ramalho, 6, 1495-165 Algés, Portugal.

|March 27, 2024

概括

大西洋鱼油经过加工,制造出富含多可沙赫萨酸 (DHA) 的光酸胆 (LPC). 这种提取物显示出大脑健康补充和食物强化潜力,增强DHA向神经细胞的输送.

科学领域:

食品科学食品科学食品科学
生物化学生物化学
海洋生物技术海洋生物技术

背景情况:

大脑中低水平的多可萨赫萨酸 (DHA) 与阿尔茨海默氏症等神经系统疾病有关.
饮食中的DHA通过血脑屏障以溶脂酸胆 (LPC) 的形式被运输,这是首选的DHA载体.
开发高效的DHA输送系统对于神经健康和疾病预防至关重要.

研究的目的:

从大西洋鱼中生产LPC-DHA提取物,用于DHA神经丰富.
评估大西洋作为富含DHA的脂的可持续来源.
为了优化酶解水解,以提高LPC形式的DHA生物可用性.

主要方法:

大西洋鱼 (Scomber scombrus) 被用作原材料.
用Rhizomucor miehei脂酶提取和化极性脂质,将酸丁胆 (PC) 转化为LPC.
在肌肉,副产品和极性脂类提取物中分析了脂类和脂肪酸概况.

主要成果:

大西洋鱼副产品的总脂质含量高于肌肉.
脂 (PL) 在肌肉脂中比较丰富.
与最初的PC (33.6%) 相比,酶化水解显著增加了PC (55.6%) 和LPC (73.6%) 的DHA含量.

结论:

大西洋鱼是富含DHA的脂的宝贵来源.
酶性水解有效地产生了具有高DHA含量的LPC-DHA提取物.
这些提取物为提高鱼利用率和增强大脑DHA吸收提供了一个有希望的策略.

关键词:

阿尔茨海默氏症 (AD) 是一种疾病.大西洋鱼 (Scomber scombrus) 的鱼类多可萨赫萨酸 (DHA) 是一种多可萨赫萨酸.lysophosphatidylcholine 溶解胺基胆的使用情况脂质是一种脂质.

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