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基于藻类的补充剂声称减肥特性:真实性控制和科学证据证明它们的有效性
Fátima Fernandes1, Raquel Martins1, Mariana Barbosa2
1REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 Porto, Portugal.
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概括
像螺旋藻这样的藻类补充剂通过抑制碳水化合物代谢酶和清理反应性物种来显示体重管理的潜力. 需要进一步的研究来证实监管批准的有效性和安全性.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 肥胖影响全球超过6亿成年人,增加慢性疾病的风险.
- 有效的长期体重管理是具有挑战性的.
- 基于藻类的补充剂声称减肥有好处,但科学证据和安全数据有限.
研究的目的:
- 研究商业上可用的藻类补充剂Arthrospira (Spirulina) platensis和Fucus vesiculosus在抑制碳水化合物代谢酶方面的有效性.
- 评估这些藻类提取物的抗氧化和激素清除能力.
- 为EFSA和FDA等监管机构提供关于藻类补充剂安全性和有效性的数据.
主要方法:
- 在体外测试测量藻提取物对α-葡萄糖酶,α-氨酶和阿尔多减少酶的抑制.
- 对氧化 (NO) 和超氧化离子 (O2•−) 激素的激素清除活动的评估.
- 在Fucus vesiculosus和Spirulina补充剂中对颜料配置文件的化学分析,包括fucoxanthin.
主要成果:
- 螺旋藻和Fucus vesiculosus提取物显示出中度抑制α-葡萄糖酶和酶减少酶.
- 螺旋藻提取物通常比Fucus vesiculosus提取物表现出更强的酶抑制和激素清除效应.
- 在Fucus vesiculosus样本中,棕色海藻中的关键标记物富可桑显著缺席,这表明其降解.
结论:
- 商业上可用的螺旋藻和Fucus vesiculosus补充剂具有中度的酶抑制和抗氧化特性.
- 在这些体外分析中,螺旋藻似乎比Fucus vesiculosus更有效.
- 这些发现强调了需要进行质量控制和进一步调查以藻类为基础的减肥产品的安全性和有效性.
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