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基于氧化铁 (磁铁) 的纳米生物材料具有医疗应用-使用陆地模型物种进行环境危害评估

Susana I L Gomes¹, Janeck J Scott-Fordsmand², Mónica J B Amorim¹

¹Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Journal of xenobiotics

|March 27, 2024

概括

涂有PEG和PLGA的磁铁纳米颗粒对土壤无脊椎动物没有毒性. 这种纳米生物材料对陆地环境没有不可接受的风险,确保环境应用的安全性.

科学领域:

环境毒理学环境毒理学
纳米材料安全性评估
陆地生态毒理学地球生态毒理学

背景情况:

纳米生物材料 (NBMs) 在癌症诊断和治疗方面表现有前途.
评估NBM对健康和环境的影响对于安全至关重要.
涂有聚乙烯糖醇 (PEG) 和聚 (乳糖-co-糖酸) (PLGA) 的Fe3O4 (磁铁) 纳米颗粒正在研究医疗应用.

研究的目的:

评估Fe3O4 PEG-PLGA纳米生物材料在陆地生态系统中的环境影响.
为了评估涂层 (Fe3O4 PEG-PLGA) 和未涂层 (Fe3O4 NMs) 纳米粒子的毒性.
确定这些NBM对土壤无脊椎动物构成的风险.

主要方法:

在土壤无脊椎动物上进行了经合组织标准的28天和延长的56天测试.
这项研究包括模型生物:Enchytraeus crypticus (Oligochaeta) 和Folsomia candida (Collembola).
评估的终点包括测试生物的生存,繁殖和大小.

主要成果:

在所有评估的终点中,没有观察到Fe3O4 PEG-PLGA或未涂层Fe3O4 NMs的毒性.
没有对Enchytraeus crypticus和Folsomia candida的生存,繁殖和大小产生不利影响.
结果表明,在测试的陆地土壤环境中,没有任何不良影响.

结论:

纳米生物材料Fe3O4 PEG-PLGA对陆地环境没有任何不可接受的风险.
这些发现支持Fe3O4 PEG-PLGA在潜在的环境应用中安全使用.
对NBM的环境命运和影响进行进一步的研究是有必要的.

关键词:

这种动物叫Enchytraeus crypticus.这种病名为folsomia candida.LUFA 2.2 土壤土壤先进的材料先进的材料.长期的长期的长期的标准测试标准测试标准测试

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