由于Wickerhamomyces anomalus引起的真菌病 - - 一个叙述性综述
Petros Ioannou1, Stella Baliou1, Diamantis P Kofteridis1
1School of Medicine, University of Crete, 71003 Heraklion, Greece.
Pathogens (Basel, Switzerland)
|March 27, 2024
概括
维克拉菌异常是一种新兴的真菌病原体,会引起感染,特别是在新生儿和ICU患者身上. 这种酵母对常见的抗真菌药物耐药性最小,但死亡率仍然很高,需要进一步研究.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 以前被称为Hansenula anomala,Pichia anomala或Candida pelliculosa的Wickerhamomyces anomalus越来越多地被认为是一种新兴的人类病原体.
- 由W. anomalus引起的人类感染的报道频率越来越高,突出其临床意义.
研究的目的:
- 审查和综合有关流行病学,抗真菌耐药性,临床特征,治疗和由Wickerhamomyces anomalus引起的真菌病的结果的数据.
- 从已发表的报告中整合信息,以更好地了解这种新兴的传染病原体.
主要方法:
- 使用PubMed/Medline,Cochrane图书馆和Scopus数据库进行了系统的文献搜索.
- 从36项涉及170名患有W. anomalus真菌病的患者的研究中提取和分析了数据.
主要成果:
- 该研究包括170名患者,平均年龄为22.8岁;超过37名是新生儿,54%是男性.
- 常见的危险因素包括使用中央静脉导管 (70.4%),全腹腔营养 (28.7%) 和重症监护室 (ICU) 住院 (39.4%).
- W. anomalus对可纳,赤甘和B.安福特的抗真菌耐药性很小. 发烧 (95.8%) 和败血症 (86%) 是最常见的表现. 总体死亡率为20%.
结论:
- Wickerhamomyces异常真菌病主要影响弱势群体,包括新生儿和ICU患者,经常与侵入性设备相关联.
- 酵母对标准的抗真菌疗法具有较低的耐药性,但整体死亡率需要谨慎的临床管理.
- 进一步的多中心研究对于全面描述患者个人资料,优化治疗策略和改善W. anomalus感染的结果至关重要.
关键词:
在Candida pelliculosa中,我们可以看到Candida.它们是 Endomyces anomalus 的类型.汉塞努拉异常症 (Hansenula anomala) 是一种异常症.皮奇亚 (Pichia anomala) 是一个不正常的植物.这是Wickerhamomyces异常.菌病 (Fungemia) 是一种真菌病.更多相关视频
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