在哺乳母猪中,Ochratoxin A的毒动力学,分泌模式和牛奶传播
Qiufeng Zhu1, Honglei Qu1, Ruifen Kang1,2
1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Toxins
|March 27, 2024
概括
这项研究跟踪了哺乳母猪的Ochratoxin A (OTA),在9小时发现血水平的峰值,并通过便和尿液显著分泌. 在牛奶中检测到OTA残留物,突出了潜在的食品安全问题.
科学领域:
- 兽医毒理学 兽医毒理学
- 食品安全 食品安全
- 动物的新陈代谢
背景情况:
- 毒素A (OTA) 是一种在料中普遍存在的真菌毒素,因毒和肝毒作用而闻名.
- 通过动物产品的污染对动物健康和人类食品安全构成风险.
- 了解牲畜中的OTA毒动力学对于风险评估至关重要.
研究的目的:
- 为了研究Ochratoxin A在哺乳母猪中的毒动学,分泌模式和牛奶传播.
- 随着时间的推移,量化OTA及其代谢物OTα在血,便,尿液和牛奶中的度.
- 为了确定牛奶与血的比率,并评估牛奶中OTA的存在.
主要方法:
- 哺乳母猪接受了单次口服剂量的奥克拉托辛A (500微克/体重).
- 在120小时内系统收集血,便,尿液和牛奶样本.
- 使用超高性能液态染色体协同质谱法 (UPLC-MS/MS) 进行OTA和OTα的定量分析.
主要成果:
- 血OTA度的峰值 (920.25±88.46μg/L) 发生在服用后9小时.
- 终端清除半衰期为78.47 ± 7.68小时;分布体积为0.16 ± 0.003 L/kg.
- 便和尿液分别占排泄总量的18.70%和8.40%.
- 在母猪牛奶中检测到OTA残留物,牛奶与血的比率在24小时内增加到0.46.
结论:
- 这项研究提供了Ochratoxin A在哺乳母猪中毒动学的全面时间分析.
- 显著的OTA分泌通过便和尿液发生.
- 牛奶中OTA的存在表明人类通过乳制品接触的潜在途径.
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