长期环境甲基暴露与亚马逊土著人口中的外围神经病变和认知障碍有关
Bruno H Rebouças1, Gabriel T Kubota1,2, Rogério A A Oliveira1
1Department of Neurology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP), Sao Paulo 05403-000, Brazil.
Toxics
|March 27, 2024
概括
亚马逊金矿的污染损害了土著人口. 雅诺玛米人头发样本中的高含量与神经损伤风险增加有关,包括外围神经病变和认知障碍.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 土著健康土著健康
背景情况:
- 亚马逊盆地面临着来自黄金开采的广泛污染.
- 长期暴露于可能会导致土著社区的神经问题.
- 需要进行研究来量化对这些人群的神经影响.
研究的目的:
- 为了研究长期暴露于扬诺玛米土著人口中的的神经效应.
- 评估与水平相关的认知,运动,协调和感官功能.
- 为了确定与高甲基暴露相关的神经缺陷的患病率.
主要方法:
- 一项涉及154名亚诺玛米族人的横截面研究.
- 神经学检查包括认知,运动和感官评估.
- 在头发样本中实验室分析甲基含量.
主要成果:
- 平均毛发甲基含量为3.9±1.7μg/g,其中10.3%超过6.0μg/g.
- 头发≥6.0μg/g的个体表现出显著更高的外围神经病变 (78.8%) 和认知能力下降 (95.9%) 的患病率.
- 含量升高与神经功能障碍风险增加有关.
结论:
- 长期暴露于对亚马逊亚诺玛米人群构成显著的神经毒性风险.
- 观察到的神经缺陷可能是不可逆转的.
- 迫切需要采取公共卫生干预措施,以减轻暴露及其对健康的影响.
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