与水平和神经症状相关的单核酸多态:概述
Jamila Alessandra Perini1,2, Jessica Vilarinho Cardoso1, Alana de Oliveira Knesse1
1Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.
Toxics
|March 27, 2024
概括
一些遗传变异或单核酸多态 (SNP) 增加了对 (Hg) 毒性和神经认知障碍的敏感性. MT1A rs8052394 SNP 可以识别出暴露于的风险较高的个人.
科学领域:
- 环境健康 环境健康
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
背景情况:
- (Hg) 污染构成全球健康风险,影响环境和人类福祉.
- 单核酸多态 (SNP) 越来越多地被认为是它们在调节Hg水平和相关健康结果中的作用.
研究的目的:
- 系统地审查和综合有关暴露于的个体遗传易感性的证据,重点关注神经认知障碍的发展.
- 为了确定特定的基因和SNP影响毒动力学和神经功能在暴露的人群.
主要方法:
- 在三个数据库中对观察性和实验性研究进行了系统审查.
- 分析包括了13篇高质量的文章 (质量评分为82-100%),评估了8124人.
- 研究主要评估了通过鱼类消费的暴露,其中31%的报告水平超过了参考限值.
主要成果:
- 八个SNP (ALAD rs1800435,CYP3A4 rs2740574,CYP3A5 rs776746,CYP3A7 rs2257401,GSTP1 rs1695,MT1A rs8052394,MT1M rs2270836,MT4 rs11643815) 与对更高Hg水平的遗传易感性有关,这些SNP的研究结果显示,这些SNP与高Hg水平的遗传易感性有关.
- 三个SNP (MT1A rs8052394,MT1M rs2270837,MT2A rs10636) 与中毒的神经毒性风险有关.
- MT1A rs8052394 SNP 证明了与更高的血水平和神经毒性风险的相关性.
结论:
- MT1A rs8052394 SNP可以作为一种有价值的生物标志物,用于识别风险增加的个体.
- 这种SNP可以帮助预测暴露于的人群中的更高的含量和随后的神经认知障碍的发展.
- 了解遗传易感性对于针对污染的针对性公共卫生干预至关重要.
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