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研究进展MicroRNA与术后认知功能障碍之间的关联

Yuanping Zhong¹, Yu Zhang¹, Zhaoqiong Zhu²

¹Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Minerva anestesiologica

|March 27, 2024

概括

手术后认知功能障碍 (POCD) 是一种常见的手术并发症. 本综述探讨了微RNAs (miRNAs) 如何可能导致POCD.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

手术后认知功能障碍 (POCD) 是手术后的重大临床挑战.
波多野结衣症的潜在机制尚未完全理解,但可能涉及神经炎症,氧化应激和亡.

结论:

微RNA代表了一个有前途的研究领域,用于解开POCD的复杂性.
对基于miRNA的生物标志物和治疗方法的进一步研究可能会对手术后认知功能障碍的管理产生重大影响.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...