尽管肺功能正常,但肌肉氧化受损在2型糖尿病中没有并发症
Islem Jlali1, Imen Touil2, Hassen Ibn Haj Amor3
1Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, France.
2型糖尿病患者的肺功能正常,但运动期间肌肉氧化受损. 这有助于降低峰值氧气消耗,这表明运动计划应该专注于改善肌肉的氧气输送.
科学领域:
- 运动生理学 运动生理学
- 心肺功能 心肺功能
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2D) 中的长期高血糖会对肺功能和肌肉氧化产生负面影响.
- 这些障碍可以阻碍生理适应体力劳动的生理适应.
研究的目的:
- 为了评估与没有糖尿病的匹配对照组相比,患有T2D (无并发症) 的超重/肥胖成年人最大运动期间的氧气通路.
- 具体评估对肺功能和肌肉氧化的影响.
主要方法:
- 用近红外光谱测试进行最大限度的增量运动测试,用于监测肌肉氧化.
- 运动前后的肺功能评估和动脉血液气体分析.
- 对15名患有T2D的超重/肥胖成年人和15名没有糖尿病的匹配对照进行了比较.
主要成果:
- 两组人都表现出正常的休息和运动后的肺体积;没有观察到显著的螺旋测量变化.
- 在T2D组显示,在最大运动期间,总和脱氧血红蛋白的增加显着较低.
- 尽管身体活动和心率相似,但T2D组的峰值氧气消耗 (V̇o2peak) 较低.
结论:
- 患有T2D的人,即使没有并发症,也保持正常的休息肺功能.
- 运动期间骨肌的氧化受损,由于血液体积减少和脱氧变化,可能会导致较低的VO2峰值.
- 对这一群体的运动干预措施应该针对肌肉氧化和血液流动的增强.
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