在玻璃眼神经保护临床试验期间药物诱导的肝损伤
Aakriti Garg Shukla1, George A Cioffi, Jeffrey M Liebmann
1Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Journal of glaucoma
|March 27, 2024
概括
尼古丁胺 (维生素B3) 显示出对玻璃眼治疗的潜力,但在临床试验中报告了严重的肝损伤不良事件. 在治疗期间,患者和医生应监测药物诱导性肝损伤 (DILI).
科学领域:
- 眼科医生 眼科 眼科
- 神经保护是一种神经保护.
- 临床药理学 临床药理学
背景情况:
- 尼古丁胺 (维生素B3) 正在全球范围内进行研究,以确定其在绿眼治疗中的神经保护作用.
- 许多临床试验正在进行中,有超过1300名参与者被定位为入学.
- 玻璃眼患者也可以在没有医疗监督的情况下使用尼古丁胺胺作为补充剂.
研究的目的:
- 报告药物诱导性肝损伤 (DILI) 的严重不良事件,与尼古丁胺胺相关,在玻璃眼临床试验中.
- 提高医疗界对潜在的DILI风险的认识.
- 鼓励在接受尼古丁胺胺治疗青光瘤的患者中对DILI保持警.
主要方法:
- 在临床试验中发生严重不良事件的案例报告 (NCT05695027).
- 评估尼古丁胺胺剂量 (每天3克) 与不良事件之间的可能关系.
- 审查正在进行的全球临床试验,涉及尼古丁胺胺治疗青光眼.
主要成果:
- 美国一项青光眼临床试验的参与者经历了药物诱导性肝损伤 (DILI).
- DILI可能与每天3克尼古丁胺胺的服用有关.
- 这凸显了尼古丁胺胺试验中患者的潜在安全问题.
结论:
- 对DILI的警对于研究人员,医生和尼古丁胺胺玻璃眼试验中的患者至关重要.
- 这些发现强调了在使用尼古丁胺时进行医疗监督的重要性,即使是作为补充剂.
- 进一步的安全监测是必要的尼古丁胺作为潜在的神经保护疗法对玻璃眼.
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