身体活动和发生的肥胖在整个肥胖遗传风险的频谱
Evan L Brittain1,2, Lide Han2,3, Jeffrey Annis4
1Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
JAMA network open
|March 27, 2024
概括
对肥胖的更高遗传风险需要更多的日常步骤来防止体重增加. 目前的体力活动指南可能对具有高遗传倾向的肥胖个体来说不够.
科学领域:
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
- 个性化医疗是个性化的医疗.
背景情况:
- 尽管有公共卫生建议,但美国的肥胖率仍在增加.
- 目前的体力活动指南不考虑个体遗传变异性.
- 遗传因素显著影响肥胖风险.
研究的目的:
- 探索更高体重指数 (BMI) 的遗传风险与减少肥胖发病率所需的体力活动水平之间的关联.
- 量化遗传倾向对身体活动预防肥胖的有效性的影响.
主要方法:
- 利用了来自我们所有人的研究计划 (AoURP) 的活动,临床和遗传数据.
- 包括以美国人口为基础的欧洲血统参与者的回顾性队列,具有活动跟踪数据和没有基线肥胖.
- 分析了BMI的每日步数和多基因风险评分 (PRS).
主要成果:
- 在PRS四分位数中,肥胖发病率从13%增加到43% (P <1.0 × 10-20).
- 较高的PRS与肥胖风险增加有关 (81%的增加,P<3.57 × 10-20).
- 与第50个百分位相比,第75个PRS百分位中的个人需要每天额外步行2280步,以达到可比的肥胖风险.
结论:
- 在不同的遗传背景和基线BMI中量化了每日步数和肥胖风险之间的关联.
- 基于人口的体育活动建议可能低估了预防遗传风险个体肥胖的必要步骤.
- 强调需要个性化体育活动指南,考虑到遗传风险.
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