长期注射HIV抗逆转录病毒疗法的患者教育和决策支持:与瑞安·怀特艾滋病毒/艾滋病计划的工具开发和试点测试协议 纽约的医疗病例管理计划
Mary Kathryn Irvine1, Rebecca Zimba2,3, Tigran Avoundjian1
1Bureau of Hepatitis, HIV and Sexually Transmitted Infections (BHHS), New York City Department of Health and Mental Hygiene, New York, NY, United States.
JMIR research protocols
|March 27, 2024
概括
长效注射 (LAI) 抗逆转录病毒疗法 (ART) 为患有日常口服ART坚持挑战的患者提供了替代方案. 这项研究调整了瑞安·怀特艾滋病毒/艾滋病计划服务,以整合LAI ART选项,旨在改善健康结果.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 长效注射 (LAI) 抗逆转录病毒疗法 (ART) 为改善HIV病毒抑制和减少传播提供了重大机会.
- 每日口服ART坚持的障碍需要探索艾滋病毒感染者的替代治疗方式.
- 瑞安·怀特艾滋病毒/艾滋病计划A部分医疗病例管理 (MCM) 计划解决护理障碍,但需要加强可持续病毒抑制策略.
研究的目的:
- 调整和扩展瑞安·怀特的MCM服务策略,以整合LAI ART方案.
- 改善那些可以从日常口服ART的替代品中受益的人群的健康结果.
- 提高LAI ART在治疗艾滋病毒中的效用.
主要方法:
- 利用与患者和提供者的焦点小组来了解LAI与日常口服ART的看法.
- 雇佣了离散选择实验 (DCE) 调查,以量化对ART交付选择和支持的偏好.
- 进行了一项非随机试验,以评估MCM计划中新开发的以患者为导向工具的实施和实用性.
主要成果:
- 该研究于2021年4月启动,并于2021年5月获得IRB批准.
- 专注组 (n=21) 和DCE (n=378) 已完成,试点工具将于2023年5月之前开发.
- 从2023年5月到2024年1月,正在进行一项注册200多名患者的试验.
结论:
- 该研究旨在提供有关LAI ART决策中以患者为导向工具的可接受性,可行性,适当性和实用性的证据.
- 主要优势包括工具开发的形成性研究,混合方法方法和安全网设置中的现实世界测试.
相关概念视频
Retrovirus Life Cycles
45.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.9K
Health Literacy
4.0K
Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
4.0K
Clinical Trials: Overview
2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
Sexually Transmitted Infections
306
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
306
Drug Administration and Therapy Phases: Overview
457
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
457


