动脉旋转标记磁共振成像和 perfusion 模式在神经认知和其他精神障碍:一个系统的审查
Rita Ferreira1, António J Bastos-Leite2
1Faculty of Medicine, University of Porto, Porto, Portugal.
Neuroradiology
|March 27, 2024
概括
脑 perfusion 异常,包括 hypoperfusion 和 hyperperfusion,是各种认知和心理健康障碍的关键指标. 这些发现有助于诊断诸如阿尔茨海默氏症和精神分裂症等疾病.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 脑输液成像对于理解神经和精神疾病至关重要.
- 以前的研究已经在各种认知和心理健康障碍中探索了 perfusion 异常.
研究的目的:
- 对认知衰退和精神健康障碍患者的大脑输液的原始研究研究进行审查.
- 识别与不同疾病相关的共同和独特的 perfusion 模式.
主要方法:
- 2011年至2023年间发表的33项原始研究的系统审查.
- 研究利用了国际医学磁共振学会和欧洲科学技术合作协会的共识指南.
- 包括具有主观认知衰退,神经认知障碍和各种精神疾病的参与者.
主要成果:
- 低流是认知衰退的全谱的一个主要发现.
- 在轻度认知障碍 (MCI),阿尔茨海默氏症 (AD) 和血管认知障碍 (VCI) 中观察到区域性过.
- 特定的低流区域有助于诊断阿尔茨海默氏症 (前,后带) 和前叶退化 (前带,前区域).
- 精神分裂症表现为时皮层过和前额外带膜前额外带膜过.
- 双极性和严重抑郁症患者表现出异常的低管输液.
结论:
- 大脑输液异常有助于诊断大多数神经认知障碍.
- 特定的输液模式可以区分AD和FTLD等疾病.
- 在VCI和其他精神疾病中,输血异常是异质的,并且不太容易泛化.
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