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基线BMI和基线疾病严重程度之间的相互作用预测,在第一发精神分裂症患者中,负面症状的改善更大
Xiaobing Sun1, Ruiqing He1, Yuan Xiao2
1Jiahui International Hospital (Shanghai), Shanghai, China.
European archives of psychiatry and clinical neuroscience
|March 27, 2024
概括
基线体重指数 (BMI) 和精神分裂症 (SCZ) 严重程度相互作用,预测第一发症患者接受RISPERIDONE治疗的负面症状改善. 这一发现有助于个性化早期SCZ治疗策略.
科学领域:
- 精神病学是一个精神病学.
- 临床神经科学 临床神经科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症 (SCZ) 患者经常超重/肥胖,影响抗精神病治疗反应.
- 基线症状严重程度是SCZ中抗精神病疗效的已知预测指标.
- 在SCZ的负面症状是特别具有挑战性的治疗和影响患者的结果.
研究的目的:
- 调查基线体重指数 (BMI),疾病严重程度和第一发作和未服用药物 (FEMN) SCZ患者的负面症状改善之间的关联.
- 为了确定基线BMI和/或疾病严重程度是否预测早期SCZ的治疗反应.
- 探索BMI和疾病严重程度之间影响负面症状结果的相互作用.
主要方法:
- 一组241名FEMN SCZ患者接受了口服Risperidone治疗3个月.
- 基线和3个月后续评估包括临床症状和身体质量指数 (BMI) 的阳性和阴性综合征量表 (PANSS).
- 使用线性回归分析来检查基线变量与负症状改善之间的关联和相互作用.
主要成果:
- 基线BMI与FEMNSCZ患者的基线症状严重程度相关.
- 无论是基线BMI还是基线疾病严重程度,都与在RISPERIDONE治疗3个月后消极症状的改善有关.
- 发现基线BMI和疾病严重程度之间的显著相互作用预测了负面症状的改善,即使在控制共变量后也是如此.
结论:
- 基线BMI和疾病严重程度的相互作用是SCZ早期负面症状改善的重要预测因素.
- 这些发现表明,基线人体测量和临床特征可以为SCZ提供个性化治疗方法.
- 需要进一步的研究来验证这些预测因素,并探索它们在指导负面症状的RISPERIDONE治疗中的临床实用性.
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