在患有炎症性肠病的患者中构建EQ-5D-5L的有效性 - - 这是一项基于瑞典炎症性肠病登记处的真实数据的研究
Jack Latteur1, Olivia Ernstsson2, Evalill Nilsson2,3
1Health Economic and Policy Research Group, Medical Management Centre, Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Stockholm, Sweden.
Journal of patient-reported outcomes
|March 27, 2024
概括
在炎症性肠病 (IBD) 患者中,EQ-5D-5L有效地测量了与健康有关的生活质量,显示了活跃疾病和缓解之间的显著差异. 这证实了它在IBD注册和研究中的使用.
科学领域:
- 胃肠病学 胃肠病学
- 健康 结果 研究 研究 结果
- 心理测量 心理测量 心理测量
背景情况:
- 自2012年以来,瑞典炎症肠病登记处 (SWIBREG) 使用EQ-5D-5L收集与健康有关的生活质量 (HRQoL) 数据.
- 有限的研究评估了EQ-5D-5L在炎症性肠病 (IBD) 患者中的有效性.
研究的目的:
- 评估EQ-5D-5L在一大群IBD患者的构造有效性,包括性结肠炎和克罗恩病.
主要方法:
- 利用来自SWIBREG的个体级数据,包括EQ-5D-5L和疾病特异性措施.
- 通过比较活跃IBD和缓解IBD患者之间的EQ-5D-5L得分来评估已知组的有效性.
- 通过将EQ-5D-5L结果与短期健康量表和医生全球评估等措施相关联,评估了收有效性.
主要成果:
- 分析了9769名IBD患者;活跃疾病患者报告的健康问题明显多于缓解期患者 (p < 0.001).
- 在大多数EQ-5D-5L维度中,活跃和非活跃疾病之间的差异效应大小小小到中等.
- 收有效性得到了支持,EQ-5D-5L结果与79%的假设与疾病特异性措施相关,如预期的那样.
结论:
- 这项研究支持EQ-5D-5L用于测量IBD患者HRQoL的构造有效性.
- 这些发现对于在卫生登记册和涉及IBD的临床/经济研究中选择HRQoL措施至关重要.
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