通过Omnipod®系统在狗中进行皮下胺剂的药理动力学
Claudia Colón1, Peter Early1, Karen Muñana1
1College of Veterinary Medicine, NC State University, Raleigh, North Carolina, USA.
Journal of veterinary pharmacology and therapeutics
|March 27, 2024
概括
欧姆尼波德®装置成功地将皮下胺给狗进行了术后的治疗. 这项研究探讨了胺及其代谢物诺克胺治疗疼痛的药理动力学.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 胺是具有止痛和抗抑郁功能的麻醉剂.
- 诺克胺是一种活性代谢物,有助于凯胺的止痛作用.
- 传统的胺注射途径包括静脉注射,皮下注射和肌肉内注射.
研究的目的:
- 评估使用Omnipod®装置在狗中进行皮下胺剂的可行性.
- 通过Omnipod®在狗中进行皮下注射后,确定胺和诺基胺的药理动力学.
主要方法:
- 欧姆尼波德 (Omnipod®) 设备被用于在狗中进行皮下胺注射 (1 mg/kg超过1小时) 的治疗.
- 测量了胺及其代谢物诺克胺的血度.
- 分析了药理动力学参数,包括血最高度 (Cmax) 和达到峰值度 (Tmax) 的时间.
主要成果:
- 欧姆尼波德®系统在术后成功地将皮下胺给狗.
- 胺的血度在42至326.1 ng/mL之间,中位数Cmax为79.5 ng/mL,Tmax为60分钟.
- 诺克胺的血度在22.0至64.8 ng/mL之间,中位数Cmax为43.0 ng/mL,Tmax为75分钟.
结论:
- 使用Omnipod®设备对狗进行皮下胺剂的注射是可行的.
- 药物动力学特征表明,在狗患者中,术后疼痛管理的潜力很大.
- 需要进一步的研究,以充分阐明这种输送方法的治疗含义.
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