基于Janus灵活传感器系统的动态外周血液输血分布监测
IEEE transactions on bio-medical engineering
|March 27, 2024
概括
一个新的Janus柔性 perfusion (JFP) 传感器系统实时监测周围血 perfusion,证明对动作文物不敏感. 这项创新有助于规划有效的循环增强治疗外周血管疾病.
科学领域:
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
- 生理学 生理学 生理学
背景情况:
- 周围血管疾病是全球重要的健康问题.
- 精确的实时监测周围输血是优化治疗策略和改善循环结果的关键.
研究的目的:
- 开发和验证一个新的Janus柔性 perfusion (JFP) 传感器系统,用于动态的外周血 perfusion 监测.
- 评估系统对运动工件的强度及其在临床场景中的有效性.
主要方法:
- 一个具有变化的扬斯模量的Janus柔性 perfusion (JFP) 传感器被设计成减轻运动工件.
- 基于光学 perfusion 模型开发了一个外周 perfusion 指数 (PPI),并在体外验证.
- 通过运动工件测试,诱导血管封闭和间歇性气压压缩治疗期间的监测来评估系统性能.
主要成果:
- 与刚性传感器相比,JFP传感器在运动时的噪音水平降低了五倍.
- 开发的外周输液指数 (PPI) 与激光多普勒流量计 (LDF) 显示出强烈的相关性 (R2=0.92) 并与估计血液输液改善的基本一致性 (kappa=0.78).
- 该系统有效地区分了不同的外周血 perfusion 状态.
结论:
- 拟议的Janus柔性 perfusion (JFP) 传感器系统可以实时监测外围血 perfusion 的变化.
- 这种传感系统提供了一个有价值的功能模块,用于在临床干预期间实时估计外周输血.
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