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Updated: Jun 29, 2025

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使用基于纳米细胞的结合和功能查来定义T细胞受体谱

Doyeon Koo1, Zhiyuan Mao2, Robert Dimatteo3

  • 1Department of Bioengineering, University of California, Los Angeles, CA 90095.

Proceedings of the National Academy of Sciences of the United States of America
|March 27, 2024
PubMed
概括

研究人员开发了纳米细胞来隔离和测序T细胞受体 (TCRs) 用于免疫治疗. 该方法识别了向病毒和癌症抗原的功能性TCR,推动了T细胞治疗的发展.

关键词:
在TCR免疫疗法免疫疗法.TCR 测序的测序方法单细胞分泌分析分析

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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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