青春期的时间:一个生命过程途径,将生命早期的风险与成人心脏代谢健康联系起来
Maria E Bleil1, Bradley M Appelhans2, Steven E Gregorich3
1Child, Family, & Population Health Nursing, University of Washington, Seattle, WA, United States of America.
PloS one
|March 27, 2024
概括
晚期青春期开始与更好的成人心脏健康有关. 早期生活因素会影响这种途径,这表明青春期的时间是预防心脏代谢疾病的关键.
科学领域:
- 生命过程流行病学的流行病学.
- 健康和疾病的发育起源.
背景情况:
- 心脏代谢风险因素通常在成年时出现.
- 早期的暴露会影响长期的健康发展轨迹.
- 青春期计时在调解这些影响中的作用需要进一步研究.
研究的目的:
- 测试检查青春期时间的生命过程模型,作为将青春期前风险因素与成人心脏代谢健康联系起来的途径.
- 确定影响心脏代谢风险的特定青春期前因素和青春期时间指标.
主要方法:
- 来自NICHD早期儿童护理和青年发展研究 (SECCYD) 和其30年后续研究 (SHINE) 的655名女性参与者的分析.
- 评估青春期前风险因素:母亲初经年龄,孩子的种族/种族,健康状况和逆境.
- 测量青春期的时间 (乳腺/阴毛发育,初潮) 和成年期心脏代谢风险 (CMR) 组合.
主要成果:
- 乳腺发育的晚期开始,阴毛发育和初潮都预测了较低的成年期CMR.
- 青春期计时指标调解了青春期前风险因素对成年期CMR的影响.
- 确定的特定途径包括母亲初经年龄,种族/种族,儿童BMI和SES通过青春期时间影响CMR.
结论:
- 青春期发育时间是一个重要的途径,将早期生命暴露与成人心脏代谢健康联系起来.
- 这些发现强调了青春期的时间作为监测和干预的潜在目标,以改善长期健康结果.
- 了解这些途径可以为预防心脏代谢疾病的策略提供信息.
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