腹部白胆能投射神经元的不同亚群编码嗅觉刺激的价值
Ronald Kim1, Mala R Ananth2, Niraj S Desai2
1Genetics of Neuronal Signaling Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Cell reports
|March 27, 2024
概括
腹皮 (VP) 中的两个不同的胆能神经元群体对不同的气味价值反应. 在VP中的胆固醇信号传递对于接近行为至关重要,但不是避免行为.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉加工 嗅觉加工
- 行为神经科学 行为神经科学
背景情况:
- 腹皮 (VP) 中的胆能投射神经元在激发行为中发挥作用.
- 了解这些神经元在处理嗅觉信息中的特定功能至关重要.
研究的目的:
- 调查VP胆固醇神经元在处理食欲 (APP) 和厌恶 (AV) 嗅觉刺激中的功能.
- 识别VP胆固醇系统内的不同神经元群体及其在接近和回避行为中的作用.
主要方法:
- 利用cFos表达和成像来评估VP胆固醇神经元中的神经元活动.
- 在选择性标记和再激活研究中使用了Cre-dependent病毒载体.
- 检查了对APP和AV气味的行为反应.
- 进行了电生理学记录和追踪到底侧杏仁体的投影.
主要成果:
- 暴露于APP或AV气味激活了不同的,不重叠的VP胆能神经元群体.
- 这些子群体表现出不同的电生理学特性,形态和投影.
- 发现VP中的胆固醇信号对于接近行为至关重要,但对于回避行为却不至关重要.
结论:
- 视觉皮质内有两个不同的胆固醇神经元子群,它们以不同的方式编码嗅觉刺激的价值.
- 这些子群体在调解方法与回避行为方面发挥着专门的作用.
- 在VP中,胆固醇信号传递是专门用于调解接近行为所需要的.
关键词:
科普:神经科学:神经科学是一门课.乙烯基胆是一种方法的方法的方法的方法.避免是避免了避免.基本侧面的杏仁体这是一种胆固醇性胆固醇.天生的行为天生的行为.神经元激活是神经元的激活瓦伦西亚的价值观腹部的白体 (Ventral Pallidum) 是一个更多相关视频
08:36Constructing an Olfactometer for Rodent Olfactory Behavior Studies Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
Published on: April 11, 2025
210
11:08Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
Published on: June 3, 2016
7.3K
相关概念视频
Olfaction
44.3K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.3K
Physiology of Smell and Olfactory Pathway
8.4K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.4K
Olfactory Receptors: Location and Structure
9.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.2K
The Physiology of Taste
3.9K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.9K
