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2型糖尿病对初级乳腺癌手术后并发症的影响:丹麦基于人口的队列研究
Kasper Kjærgaard1, Jannik Wheler1, Looket Dihge2
1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
患有乳腺癌和2型糖尿病 (T2D) 的女性面临手术并发症风险增加. 这种风险被共同疾病放大,突出了影响结果的协同效应.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 手术结果研究研究.
背景情况:
- 关于2型糖尿病 (T2D) 对乳腺癌手术结果的影响的数据有限.
- 这项研究研究了T2D与手术后并发症的关联及其与并发症的相互作用.
研究的目的:
- 研究乳腺癌患者T2D和手术并发症之间的关联.
- 评估T2D和并发症之间对并发症发生率的生物相互作用.
主要方法:
- 来自丹麦乳腺癌组数据库的98,589名早期乳腺癌患者 (1996-2022) 的队列被分析.
- 流行T2D数据来源于丹麦注册;在30天内确定了手术并发症.
- 使用考克斯回归和相互作用对比来评估并发症风险和协同效应.
主要成果:
- 6.4%的患者在手术时患有T2D. 患有T2D的女性的并发症率为16.4%,而没有的女性的并发症率为10.7% (HR 1.43).
- 由于T2D与中度和重度并发症的相互作用,手术并发症的发病率分别为21%和42%.
结论:
- 2型糖尿病显著增加了初级乳腺癌手术后手术并发症的风险.
- 二型糖尿病和并发症之间的协同作用解释了受影响患者的并发症率升高.
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