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常规上皮外角膜交叉连接在进展性角质患者中:10年后的结果

Jérémy Bordais¹, Myriam Cassagne^1,2, David Touboul³

¹Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, Toulouse, France.

|March 27, 2024

概括

传统的上皮脱角膜交叉连接 (CXL) 有效地稳定了10年的渐进性角质 (KC),显示了长时间的平整和视力改善. 重复CXL不常见,主要是在年轻患者中.

科学领域:

眼科医生眼科眼科
角膜外科手术角膜外科手术
视觉科学视觉科学视觉科学

背景情况:

角膜 (KC) 是一种渐进的角膜疾病.
角膜交叉连接 (CXL) 是渐进的KC的标准治疗方法.
表皮脱离CXL是一种常见的CXL协议.

研究的目的:

评估传统上皮质脱落CXL对渐进性KC的10年安全性和结果.
评估CXL后角膜形状和视觉功能的长期变化.
报告CXL后的并发症和不良事件.

主要方法:

从2006年至2011年接受常规CXL (德累斯顿协议) 的患者的回顾性审查.
十年后续数据分析.
主要结局:角质量变化 (Kmax,K2,K1,Km,地形气).
二次结果:视觉和折射变化,并发症.

主要成果:

在10年后,Kmax,K2,K1,Km和地形气的长期显著减少 (P < 0.00001).
在CXL后5至10年间观察到持续的平坦化.
在最佳眼镜校正的视力敏度和明显折射球形等价值显著改善.
10年重复的CXL率:4% (在18岁以下的患者中);1%的BSCVA损失>3行.

结论:

常规的上皮脱落CXL有效地稳定了随着持续平坦化的渐进式KC.
治疗后的功能性视力改善持续长达10年.
重复的CXL很少见,主要用于年轻的KC患者.

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