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Updated: Jun 29, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

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一种新型抗生素药物组合对抗多抗药性眼睛病原体的有效性

Lakshminarayanan Gowtham1, Rachel A F Wozniak2,3, Paul M Dunman3

  • 1Dr Chigurupati Nageswara Rao Ocular Pharmacology Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Cornea
|March 27, 2024
PubMed
概括

这项研究表明,将多素B/三甲 (PT) 与里法 (rifampin) 结合起来,可以有效地消除导致角膜炎的多抗药性 (MDR) 细菌. 这种新型药物组合为具有挑战性的细菌眼部感染提供了有希望的治疗方法.

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相关概念视频

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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