在小鼠视觉皮层中,皮层内微刺激和视觉刺激诱导的神经和血液动力学反应的激活和抑制
Naofumi Suematsu1, Alberto L Vazquez1,2,3,4, Takashi D Y Kozai1,2,4,5,6
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Journal of neural engineering
|March 27, 2024
概括
皮层内微刺激 (ICMS) 频率对神经激活和抑郁有不同的影响. 低频率有利于激活,而高频率增强抑郁,为大脑机器接口提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 感官恢复 感官恢复
背景情况:
- 皮层内微刺激 (ICMS) 是大脑机器接口 (BMI) 恢复感官知觉的关键.
- 了解ICMS机制及其与神经元活动的联系对于BMI的进步至关重要.
研究的目的:
- 研究不同微刺激频率如何影响小鼠视觉皮层中的神经元和血液动力学反应.
- 阐明ICMS期间神经激活,抑郁和血液动力学变化之间的关系.
主要方法:
- 在Thy1-GCaMP6s小鼠体内广场和两光子成像.
- 使用不同的ICMS频率量化神经激活和抑郁.
- 测量血液动力学信号 (氧血球蛋白,脱氧血球蛋白).
主要成果:
- 较低的ICMS频率优先诱导更强的神经元激活.
- 神经抑郁倾向于略高于激活的频率.
- 血液动力学信号与神经反应在空间上相匹配,在抑郁期间氧血球蛋白升高.
- 身体反应大于神经反应,激活和抑郁的频率依赖差异.
结论:
- 神经激活和抑郁机制不同,抑郁可能需要氧气供应并影响神经元.
- 这些发现为ICMS引起的神经活动提供了新的见解.
- 结果为神经设备的发展提供信息,利用激活和抑郁为目标神经反应提供动力.
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