通过声波波束介导的通过皮肤递送药物
Yuzhi Li1, Mingcong Guo1, Gepu Guo1
1School of Computer and Electronic Information/ School of Artificial Intelligence, Nanjing Normal University, Nanjing 210023, China.
Ultrasonics
|March 27, 2024
概括
声波束通过利用横向声波辐射力来增强皮肤的透性,从而增强皮肤通过皮肤传递的药物. 与传统的超声波技术相比,这种新的方法为药物运输提供了一种更有效,更可控的方法.
科学领域:
- 生物医学工程 生物医学工程
- 声学 声学 在声学方面
- 药物运输 药物运输 药物运输
背景情况:
- 超声波介导的透皮药物递送由于其安全性和可控性而具有前景.
- 目前的方法主要集中在来自平面或聚焦波的声波化上.
- 其他影响运输的物理现象,如声波辐射力,往往被忽视.
研究的目的:
- 调查声波 (AV) 束在超声中介透皮药物递送中的潜力.
- 探索横向声辐射力 (T-ARF) 在增强使用AV光束的药物传输中的作用.
- 为了比较AV光束与传统聚焦超声波的疗效.
主要方法:
- 在通过皮肤递送药物实验中引入聚焦的AV (FAV) 束.
- 测量和分析FAV光束产生的横向声辐射力 (T-ARF).
- 使用纤维素膜进行实验验证,以评估孔隙性和传递效率的变化.
主要成果:
- 尽管声强度较低,但FAV光束实现了更有效的透皮传递.
- 一个聚焦的AV光束诱导了PN级的T-ARF,促进了角层孔隙扩大.
- 实验运输表明,与非旋转束相比,使用AV束显著增加了膜透性和传递效率.
结论:
- 声波束代表了超声波介导的通过皮肤递送药物的新方法.
- 横向声辐射力是通过AV光束增强通过皮肤传输的关键机制.
- 这项技术为精确和高效的药物输送策略提供了新的自由度.
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