晨晚问卷和发生癌症之间的关系:一项历史临床队列研究
Tetyana Kendzerska1, Brian J Murray2, David R Colelli3
1Department of Medicine, The Ottawa Hospital/University of Ottawa, Ottawa, Ontario, Canada; ICES, Ottawa, Toronto, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Sleep medicine
|March 27, 2024
概括
用晨晚问卷 (MEQ) 测量的时刻型显示了与癌症风险的U形联系. 与中间类型相比,极端的早晨和晚上的时间类型都会增加癌症风险.
科学领域:
- 时间生物学 时间生物学
- 癌症流行病学 癌症流行病学
- 睡眠医学 睡眠医学
背景情况:
- 时代型,一个人的日常生物节奏,影响各种生理过程.
- 昼夜节律的干扰越来越多地与包括癌症在内的不良健康结果有关.
- 清晨-傍晚问卷 (MEQ) 是一个验证的工具来评估时间型.
研究的目的:
- 调查由总MEQ得分决定的时间型与发生癌症的风险之间的关联.
- 探索时间型和癌症发病率之间的潜在U形关系.
- 在分析中控制睡眠参数和并发症.
主要方法:
- 使用临床和卫生行政数据进行的回顾性队列研究.
- 纳入了接受过多睡眠扫描 (PSG) 并在2010-2015年期间完成了MEQ的成年人.
- 通过安大略省癌症登记处确定癌症状况,随访至2020年3月31日.
- 采用多变量Cox因果特异回归模型.
主要成果:
- 分析了1781名无癌症个体的队列 (平均年龄54岁,47.1%是男性).
- 在总MEQ得分和发生癌症风险之间观察到U形关系.
- 与中级时刻型相比,极端时刻型 (每天早上或每天晚上) 个体患癌症的风险增加.
- 最高的风险与非常早晨的年代型相关 (MEQ评分≥76).
结论:
- 偏离标准的昼夜倾向,以极端的时间型来表示,可能与癌症风险增加有关.
- 这种U形的联系表明,保持平衡的昼夜节律对健康至关重要.
- 需要进一步的研究,以阐明 kronotype 和恶性瘤之间的生物学机制.
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