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Updated: Jun 29, 2025

Separation of Aldehydes and Reactive Ketones from Mixtures Using a Bisulfite Extraction Protocol
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对降酶对化和碳基组的选择性差异的理论分析

Ru-De Lin1, Xiu Xing1, Yuan Yu1

  • 1Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.

Journal of chemical information and modeling
|March 27, 2024
PubMed
概括

乳酸菌酒精脱酶和克里西奥细菌sp. 由于活性口袋的结构差异,降酶表现出明显的化学选择性. 关键残留物稳定基板,使选择性减少成为可能,并提供机械洞察力.

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Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
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Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
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The carbonyl center is...
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Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
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