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Updated: Jun 29, 2025

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分子决定因素和PKA RIα相分离的信号效应

Julia C Hardy1, Emily H Pool2, Jessica G H Bruystens3

  • 1Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Molecular cell
|March 27, 2024
PubMed
概括

蛋白激酶A (PKA) 的调节子单元RIα通过液态分离 (LLPS) 形成凝结物,由二元化和cAMP释放驱动. 这个过程在空间上限制了活跃的PKA,增强了信号特异性.

关键词:
生物分子凝聚剂是生物分子凝聚剂.本质上是无序的区域.蛋白质激酶酶是一种蛋白质激酶.信号的分隔是指信号的分隔.

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