混合益生菌可以降低压力诱导的抑郁类行为严重程度
Xianguo Li1, Xukai Cheng1, Yongping Shi1
1Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Journal of affective disorders
|March 27, 2024
概括
这项研究表明,混合益生菌,包括Lacticaseibacillus rhamnosus和Enterococcus faecium,可以减少的抑郁行为. 益生菌改善了肠道健康,降低了炎症,增强了托代谢,有利于心理健康.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 人们越来越认识到肠道微生物在心理健康中的作用.
- 益生菌干预正在研究焦虑和抑郁症.
- 了解肠-大脑轴对于开发新的治疗策略至关重要.
研究的目的:
- 研究混合益生菌 (Lacticaseibacillus rhamnosus和Enterococcus faecium) 对类似抑郁的行为,肠道微生物组合和模型炎症的影响.
- 在益生菌干预的背景下,探索肠道微生物群,炎症和L-酸盐代谢之间的关系.
主要方法:
- 将混合益生菌给的子.
- 对类似抑郁的行为进行评估.
- 使用测序技术分析肠道微生物组的组成.
- 测量血清炎症因子和L-托代谢物 (5-HT,5-HTP) 的测量.
- 细菌数量,炎症和代谢标志物之间的相关性分析.
主要成果:
- 混合益生菌显著减少了的抑郁类行为.
- 益生菌治疗导致有益的肠道细菌的丰富性增加,并改善了微生物群平衡.
- 炎症因素的血清水平下降 (P < 0.05).
- 增加了L-托代谢,恢复了5-HT和5-HTP水平 (P <0.05).
- 有益细菌与炎症有负相关性,与托代谢有正相关性 (P < 0.05).
结论:
- 混合益生菌有效地恢复肠道平衡,并增强的酸盐代谢.
- 益生菌干预通过调节肠道微生物群和代谢途径来缓解炎症和抑郁症类行为.
- 这项研究支持了特定益生菌组合作为情绪障碍治疗方法的潜力.
关键词:
抑郁症 抑郁症 抑郁症类似抑郁症的行为肠球菌 (Enterococcus faecium) 是一个有毒的菌株.我们的肠道微生物群.牛奶的乳酸酶ibacillus rhamnosusus是什么意思更多相关视频
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