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通过移植共聚合技术设计的特拉加坎特-凝网络水凝的物理化学特性评估

Nistha Thakur¹, Baljit Singh¹

¹Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.

International journal of biological macromolecules

|March 27, 2024

概括

这项研究开发了用于药物输送的特拉加坎特-凝水凝,显示出良好的血液兼容性,粘膜粘合性和抗氧化特性. 这些优化的水凝为持续释放药物的应用提供受控的孔径.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
药物输送系统药物输送系统

背景情况:

由于其可调节的特性,水凝在药物输送中至关重要.
结合天然聚合物,如Tragacanth Gum (TG) 和凝,可以为先进的生物材料提供潜力.

研究的目的:

为了合成和描述用于药物输送应用的TG-凝水凝.
评估这些新型水凝的生理化学和生物医学特性.

主要方法:

TG和凝的联合聚合.
使用FE-SEM,EDAX,FTIR,NMR,TGA,DSC和XRD进行表征.
使用欧洛素和科尔斯迈耶-佩帕斯模型的药物释放研究.
生物医学评估包括血液兼容性,粘膜粘合和抗氧化活性 (DPPH测定).

主要成果:

FE-SEM显示异质形态;XRD显示无形性质.
奥夫洛克萨的释放跟随非菲克的扩散,最好用科尔斯迈耶-佩帕斯模型来描述.
水凝显示出良好的血液兼容性 (75.63±1.98%的血栓生成性) 和粘膜粘合性 (119±8.54mN的脱离力).
抗氧化剂活性显示有65.71 ± 3.68%的自由基抑制.
优化水凝的交联密度为2.227 × 10−4 molcm−3 和网状尺寸为7.966 nm.

结论:

TG-凝共聚合物适用于药物输送应用.
通过调整单体和交叉连接器含量来实现受控的网络孔径大小.
开发的水凝对持续的药物输送系统有很大的前景.

关键词:

药物输送是药物输送的过程.水凝是一种水凝.超分子相互作用

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