肥胖和体外膜氧化的情况
Dana E Coccola1, Kenneth E Remy2, Ira M Cheifetz3
1Division of Critical Care, Department of Pediatrics, UH Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, Cleveland, Ohio. dana.coccola@uhhospitals.org.
肥胖不会增加患者体外膜氧化 (ECMO) 的风险. 目前的证据表明,肥胖并不是将患者排除在ECMO治疗之外的理由.
科学领域:
- 临界护理医学 临界护理医学
- 支持心肺血管的支持.
- 肥胖医学 肥胖医学
背景情况:
- 全球肥胖率的上升给重症监护带来了挑战.
- 肥胖在理论上与严重疾病的发病率和死亡率增加有关.
- 从历史上看,肥胖是体外膜氧化 (ECMO) 的禁忌.
研究的目的:
- 综合当前关于肥胖患者体外膜氧化 (ECMO) 结果的文献.
- 评估需要ECMO的患者肥胖和结果之间的关联.
- 确定身体质量指数是否应该成为ECMO的排除标准.
主要方法:
- 在PubMed,Scopus和CENTRAL数据库中的系统文献搜索.
- 包括检查肥胖和ECMO结果的研究.
- 由两位作者独立选和选择文章.
主要成果:
- 对29篇文章的综述 (1项宏观研究,28项回顾性队列研究).
- 分析显示,ECMO患者的死亡率或与肥胖相关的并发症没有增加.
- 目前没有证据支持使用体重指数作为ECMO的排除标准.
结论:
- 现有的文献不支持肥胖ECMO患者的死亡率或并发症增加.
- 需要进一步的前性研究才能充分理解肥胖和ECMO结果之间的关系.
- 根据目前的证据,身体质量指数不应作为ECMO候选人的排除因素.
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