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In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

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对树,人类和小鼠视网膜结构的比较体内成像.

Marta Grannonico¹, David A Miller², Mingna Liu¹

¹Department of Biology, University of Virginia, Charlottesville, Virginia 22904.

|March 27, 2024

概括

树为研究视神经病变提供了卓越的模型,因为它们的类似灵长类动物的视网膜结构. 这项研究描述了树视网膜层的特征,为了解人类眼睛疾病提供了基础.

关键词:

在活体中成像成像在老鼠视网膜上.视网膜层结构视网膜层结构 IPL 的下层 IPL 的下层.树木,树木,树木,树木,树木.对于OCT来说,这是一个很好的选择.

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科学领域:

眼科医生眼科眼科
比较解剖学的比较解剖学
神经科学是一个神经科学.

背景情况:

由于结构上的差异,动物模型对研究人类视网膜疾病有局限性.
树,白天类 paraprimates,拥有视觉敏度和视网膜结构更类似于人类.

研究的目的:

用高分辨率光学连贯断层扫描来描述树的内生视网膜结构.
为了比较树与老鼠和人类的视网膜结构.
建立树作为视神经病研究的有价值的模型.

主要方法:

高分辨率可见光光学连贯性断层扫描 (OCT) 用于体内成像.
视网膜层的定量表征,包括内状层 (IPL) 的子层.
外体共聚焦显微镜用于验证体内发现的结果.
对树,老鼠和人类视网膜结构的比较分析.

主要成果:

树视网膜结构的详细体内表征,包括IPL的新型亚层分析.
树和人类视网膜层结构之间有显著的相似之处,特别是在视网膜神经纤维层 (RNFL) 和质细胞层 (GCL).
在体内验证的OCT发现与外体共聚焦显微镜,证实了树模型的准确性.

结论:

树代表了研究人类视神经病变的高度相关的动物模型.
这项研究为未来对影响IPL,GCL和RNFL的疾病中视网膜结构变化的研究提供了基础数据.
该研究强调了OCT在比较视网膜成像和疾病建模中的实用性.