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硫素相互作用蛋白 (TXNIP) 的DNA甲基化水平与血糖特征的变化之间的关联:基于人口的纵向研究

Keisuke Maeda¹, Ryosuke Fujii^2,3, Hiroya Yamada⁴

¹Department of Clinical Physiology, Fujita Health University School of Medical Sciences, Toyoake 470-1192, Japan.

Endocrine journal

|March 27, 2024

概括

铁素相互作用蛋白 (TXNIP) 的较低DNA甲基化与四年内禁食血葡萄糖和HbA1c的增加有关. 这表明TXNIP DNA低甲基化可能预测葡萄糖代谢恶化.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
代谢性疾病研究研究.
发现生物标志物的发现.

背景情况:

铁素相互作用蛋白 (TXNIP) 对于葡萄糖代谢至关重要.
DNA甲基化 (DNAm) 调节了TXNIP的表达.
以前的研究表明TXNIP DNAm与2型糖尿病之间存在联系,但缺乏前性数据.

研究的目的:

调查TXNIP DNAm水平与血糖特征的纵向变化之间的潜在关联.
为了确定TXNIP DNA低甲基化是否预测未来葡萄糖水平的增加.

主要方法:

在2015年和2019年评估的169名参与者的长度研究.
用于量化白细胞中TXNIPDNAm的热序测定试验 (cg19693031).
后勤回归分析检查了二分体化TXNIPDNAm和葡萄糖特征变化之间的关联.

主要成果:

在基线TXNIPDNA低甲基化的参与者显示,在4年内,禁食血葡萄糖 (FPG) 和血红蛋白A1c (HbA1c) 的增加更大.
在低甲基化组中,FPG和HbA1c升高的调整后几率比率显著更高.
TXNIP DNA 低甲基化与葡萄糖特征显著增加有关.

结论:

基线白细胞TXNIPDNA低甲基化与未来血糖特征的增加有关.
白细胞中的TXNIP DNAm状态可能作为葡萄糖平衡受损的早期预测生物标志物.

关键词:

DNA甲基化 (DNAm) 是一种葡萄糖是一种葡萄糖.血红蛋白A1c (HbA1c) 是一种铁素相互作用蛋白 (TXNIP) 是一种与铁素相互作用的蛋白质.二型糖尿病 (T2DM) 是一种糖尿病.

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