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Updated: Jun 29, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

[在败血症诱导的免疫抑制中,由编程死亡-1/编程死亡-连接体1途径介导的髓质衍生抑制细胞的研究进展]

Yifei Xu¹, Xuefeng Zang, Wei Chen

¹Department of Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Corresponding author: Chen Wei,

Zhonghua wei zhong bing ji jiu yi xue

|March 27, 2024

概括

骨髓系衍生抑制细胞 (MDSC) 和PD-1/PD-L1通路是败血症诱导免疫抑制的关键参与者. 了解它们的相互作用对于治疗晚期败血症至关重要.

科学领域:

免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

败血症通过破坏身体对感染的反应而导致危及生命的器官功能障碍.
败血症的免疫抑制阶段在晚期病例中显著增加了发病率和死亡率.

结论:

这篇评论详细介绍了PD-1/PD-L1通路在败血症引起的免疫抑制过程中的机制.
讨论了在败血症中PD-1/PD-L1通路调解的时间动态.

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