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与高甘油三血症相关的急性胰腺炎的复发:一个多中心的前性队列研究
Ling Ding1, Shuai Li2, Longxiang Cao2
1Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, No. 17 Yong Waizheng Street, Nanchang, Jiangxi Province 330006, China.
复发性过高甘油血症相关的急性胰腺炎 (HTG-AP) 影响了23%的患者,尤其是患有糖尿病的年轻人. 复发导致重入医院和降低生活质量.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 关于复发性高甘油三血症相关急性胰腺炎 (HTG-AP) 的前性数据有限.
- 了解复发模式和预测因素对于患者管理至关重要.
研究的目的:
- 为了确定复发性HTG-AP的发生率.
- 为了确定复发的预后因素.
- 评估复发性HTG-AP的临床相关性,包括生活质量.
主要方法:
- 一个多中心的前性队列研究,涉及成人患者,他们的第一个HTG-AP事件.
- 随访时间超过两年,有两轮的时间表.
- 考克斯的比例危险模型用于因素分析,EQ-5D-5L用于生活质量评估.
主要成果:
- 在31个月的平均随访期间,复发性HTG-AP的发生率为23% (37/161).
- 经常出现的发作需要重新入院.
- 年龄较小 (<40岁) 和糖尿病病史是复发的重要预测因素.
- 复发的患者报告生活质量降低 (EQ VAS得分).
结论:
- HTG-AP的复发是一个重要的临床问题.
- 患有糖尿病的年轻患者患有复发性HTG-AP的风险更高.
- 复发与医疗保健利用率增加和生活质量下降有关.
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